Science & Research

Honest communication about the research supporting our ingredients.

Our Approach to Science Communication

We Believe in Honest Science

We don't cherry-pick favorable studies or exaggerate findings. We clearly distinguish between preliminary research and conclusive evidence. We acknowledge limitations and uncertainties. Science is a process of discovery, not a marketing tool.

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Evidence Hierarchy

We recognize different levels of scientific evidence:

  • Meta-analyses & systematic reviews - Highest level
  • Randomized controlled trials (RCTs) - Strong evidence
  • Observational studies - Suggestive
  • In vitro & animal studies - Preliminary
  • Traditional use - Historical context
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Research Limitations

We openly acknowledge:

  • Small sample sizes in many studies
  • Short study durations
  • Variation in study populations
  • Differences in dosing and formulations
  • Need for more research in many areas

No Miracle Claims

We are transparent about what supplements can and cannot do:

  • Supplements support, not cure
  • Individual responses vary widely
  • Lifestyle matters more than any pill
  • Medical supervision remains essential

Research on Key Ingredients

Below are summaries of research on our main ingredients. References are from peer-reviewed scientific literature.

Kudzu Root Extract (Pueraria lobata)

Traditional Use

A leguminous plant used for centuries in traditional Chinese medicine for various health purposes including metabolic support. Historical use provides context but not clinical proof.*

Modern Research

Active Compound: Rich in isoflavones, particularly Puerarin, which has demonstrated significant metabolic regulatory activity in multiple clinical studies.*

Mechanism: Research suggests Puerarin may enhance cellular response to insulin signaling, help regulate postprandial blood glucose fluctuations, and support healthy microcirculation.*

Limitations: While promising, many studies have been conducted in specific populations. Optimal dosing for different populations requires further study. More long-term human trials are needed.

References

Zhang et al. (2013). Phytomedicine. Wong et al. (2011). Journal of Ethnopharmacology. Chen et al. (2018). Frontiers in Pharmacology.

Mulberry Leaf Extract (Morus alba)

Traditional Use

Used extensively in traditional Asian medicine and recognized globally as a natural approach to blood sugar management. Widely accepted in Japan, Europe, and the Americas.*

Modern Research

Active Compound: Contains 1-Deoxynojirimycin (DNJ), a natural alpha-glucosidase inhibitor that may help slow carbohydrate breakdown and support blood sugar management.*

Mechanism: DNJ inhibits alpha-glucosidase enzymes in the digestive tract, slowing carbohydrate breakdown and reducing postprandial glucose spikes. Multiple randomized controlled trials have confirmed its effectiveness.*

Limitations: Individual responses may vary. Optimal dosing depends on meal composition. May cause mild gastrointestinal effects in some individuals.

References

Kimura et al. (2007). Journal of Agricultural and Food Chemistry. Mudra et al. (2007). Diabetes Care. Asai et al. (2011). Journal of Clinical Biochemistry and Nutrition.

Bitter Melon Extract (Momordica charantia)

Traditional Use

Widely used in traditional medicine systems across Asia, Africa, and South America for blood sugar management. One of the most extensively researched natural compounds for glucose metabolism.*

Modern Research

Active Compounds: Contains unique bioactive compounds including Charantin and Polypeptide-P, which research suggests may support cellular glucose uptake and metabolism.*

Mechanism: Acts as a natural insulin sensitizer, promoting glucose uptake in cells and providing comprehensive blood sugar support for both postprandial and fasting glucose levels.*

Limitations: Effects are dose-dependent. Study quality varies. Some individuals may experience gastrointestinal discomfort. More standardized clinical trials are needed.

References

Joseph & Jini (2013). Journal of Medicinal Food. Fuangchan et al. (2011). Diabetes Research and Clinical Practice. Krawinkel & Keding (2006). Nutrition Reviews.

Goji Berry Extract (Lycium barbarum)

Traditional Use

A globally recognized superfood with a long history in traditional medicine for general health and vitality. Known for its rich antioxidant content.*

Modern Research

Active Compounds: Rich in Lycium barbarum polysaccharides (LBP), carotenoids, and multiple antioxidant substances that provide comprehensive cellular protection.*

Mechanism: Acts as a potent antioxidant, clearing free radicals and protecting cells from oxidative damage. May support pancreatic beta-cell health and reduce metabolic oxidative stress.*

Limitations: Effects on glucose metabolism are primarily supportive through antioxidant mechanisms. Direct blood sugar lowering effects require more human clinical evidence.

References

Amagase & Nance (2008). Journal of Alternative and Complementary Medicine. Jin et al. (2013). International Journal of Biological Macromolecules. Luo et al. (2004). Life Sciences.

Chinese Yam Extract (Dioscorea opposita)

Traditional Use

A staple in traditional Chinese medicine for digestive health and metabolic support. Valued for its mucilaginous properties and nutritional content.*

Modern Research

Active Compounds: Rich in mucin proteins and dietary fiber that support gut barrier function and optimize nutrient absorption processes.*

Mechanism: May help repair intestinal mucosa, slow carbohydrate absorption, and support insulin sensitivity for long-term metabolic health maintenance.*

Limitations: Classified as a "metabolic stabilizer" ingredient - provides supportive rather than direct glucose-lowering effects. Long-term benefits require consistent use.

References

Chen et al. (2015). Carbohydrate Polymers. Ma et al. (2017). Food & Function. Shi et al. (2019). Journal of Functional Foods.

What Research Can and Cannot Tell Us

✓ What We Know

  • Our ingredients have traditional use history spanning centuries
  • Preliminary research suggests potential benefits for metabolic health*
  • Ingredients are generally recognized as safe when used as directed
  • Specific bioactive compounds have been identified and studied
  • Mechanisms of action have been proposed based on laboratory research

⚠️ What Remains Uncertain

  • Optimal dosing for different populations
  • Long-term effects beyond 1-2 years
  • Comparative effectiveness versus medications
  • Individual response predictability
  • Synergistic effects of combined ingredients
  • Effects in healthy vs. at-risk populations

❌ What We Cannot Claim

  • That our supplement treats, cures, or prevents diabetes
  • That our supplement can replace medications
  • Guaranteed specific results or timelines
  • That benefits apply equally to all individuals
  • That our specific formulation has been clinically tested

Research on Lifestyle Matters Most

The strongest scientific evidence for managing blood sugar and metabolic health points to lifestyle interventions:

Nutrition

Whole foods, high fiber, controlled carbohydrates, and balanced macronutrients have the strongest evidence base for metabolic health.

Physical Activity

Regular exercise improves insulin sensitivity more effectively than any supplement. This is conclusively demonstrated in research.

Weight Management

Even modest weight loss (5-10%) significantly improves metabolic markers in overweight individuals. This effect is well-established.

Medical Management

For diagnosed diabetes, prescribed medications have proven efficacy and should never be discontinued in favor of supplements.

Bottom Line: Supplements may provide additional support, but they are not a substitute for proven lifestyle interventions and medical treatment. Focus on the fundamentals first.